Spectroscopy - June 2009 - (Page 6) 6 Spectroscopy 24(6) June 2009 w w w. s p e c t r o s c o p y o n l i n e . c o m ® Contents Columns THE BASELINE Auger Spectroscopy J une 20 0 9 Volume 24 Number 6 14 Columnist David W. Ball discusses Auger spectroscopy, in which the energies of emitted electrons are measured. David W. Ball CHEMOMETRICS IN SPECTROSCOPY Statistics and Chemometrics for Clinical Data Reporting, Part I 18 This article describes the application of chemometric methods and statistics for reporting clinical quantitative measurement methods. Part I will introduce these concepts and Part II will discuss the statistical underpinnings in greater detail. Jerome Workman, Jr. and Howard Mark FOCUS ON QUALITY 22 Understanding and Interpreting the New GAMP 5 Software Categories The GAMP (Good Automated Manufacturing Practice) guide version 5 was released in March 2008 and one of the changes was that the classification of software was revised — again. In this column we will look at what the changes mean for the laboratory and whether all of these should be implemented. R.D. McDowall Cover image courtesy of Getty Images. Articles Current Status of Standoff LIBS Security Applications at the United States Army Research Laboratory 32 DEPARTMENTS News Spectrum Product Resources Calendar Ad Index The U.S. Army Research Laboratory (ARL) has been applying standoff laser-induced breakdown spectroscopy (LIBS) to hazardous material detection and determination. Here, the authors describe several standoff systems that have been developed. Frank C. De Lucia, Jr., Jennifer L. Gottfried, Chase A. Munson, and Andrzej W. Miziolek 12 45 48 50 Spectral Studies on the Interaction of [Ru(bpy)2(BTIP)]2+ with DNA and Determination of Nucleic Acids at Nanogram Levels 39 The interaction of [Ru(2, 2’-bipyridine)2(2-benzo[b] thien-2-yl-1H-imidazo[4,5-f][1,10] phenanthroline)]2+ ([Ru(bpy)2(BTIP)]2+) with nucleic acids in weak acidic medium is studied based upon the measurements of resonance light scattering (RLS) and UV–vis absorbance. Chao Weng, Xiaoming Chen, and Changqun Cai Spectroscopy (ISSN 0887-6703 [print], ISSN 1939-1900 [digital]) is published monthly by Advanstar Communications, Inc., 131 West First Street, Duluth, MN 55802-2065. Spectroscopy is distributed free of charge to users and specifiers of spectroscopic equipment in the United States. Spectroscopy is available on a paid subscription basis to nonqualified readers at the rate of: U.S. and possessions: 1 year (12 issues), $74.95; 2 years (24 issues), $134.50. Canada/Mexico: 1 year, $95; 2 years, $150. 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This Month in Wavelength: Raman Spectroscopy Watch your e-mail inbox for the latest issue, or follow the link at www.spectroscopyonline.com to sign up to start receiving Wavelength. http://www.spectroscopyonline.com http://www.spectroscopyonline.com http://www.spectroscopyonline.com http://www.spectroscopyonline.com Table of Contents for the Digital Edition of Spectroscopy - June 2009 Spectroscopy - June 2009 Contents News Spectrum Auger Spectroscopy Statistics and Chemometrics for Clinical Data Reporting, Part 1 Understanding and Interpreting the New GAMP 5 Software Categories Current Status of Standoff LIBS Security Applications at the United States Army Research Laboratory Spectral Studies on the Interaction of [Ru(bpy)2(BTIP)]2+ with DNA and Determination of Nucleic Acids at Nanogram Levels Product Resources Calendar Ad Index Spectroscopy - June 2009 Spectroscopy - June 2009 - (Page BB1) Spectroscopy - June 2009 - (Page BB2) Spectroscopy - June 2009 - Spectroscopy - June 2009 (Page Cover1) Spectroscopy - June 2009 - Spectroscopy - June 2009 (Page Cover2) Spectroscopy - June 2009 - Spectroscopy - June 2009 (Page 3) Spectroscopy - June 2009 - Spectroscopy - June 2009 (Page 4) Spectroscopy - June 2009 - Spectroscopy - June 2009 (Page 5) Spectroscopy - June 2009 - Spectroscopy - June 2009 (Page 6) Spectroscopy - June 2009 - Spectroscopy - June 2009 (Page 7) Spectroscopy - June 2009 - Contents (Page 8) Spectroscopy - June 2009 - Contents (Page 9) Spectroscopy - June 2009 - Contents (Page 10) Spectroscopy - June 2009 - Contents (Page 11) Spectroscopy - June 2009 - News Spectrum (Page 12) Spectroscopy - June 2009 - News Spectrum (Page 13) Spectroscopy - June 2009 - Auger Spectroscopy (Page 14) Spectroscopy - June 2009 - Auger Spectroscopy (Page 15) Spectroscopy - June 2009 - Auger Spectroscopy (Page 16) Spectroscopy - June 2009 - Auger Spectroscopy (Page 17) Spectroscopy - June 2009 - Statistics and Chemometrics for Clinical Data Reporting, Part 1 (Page 18) Spectroscopy - June 2009 - Statistics and Chemometrics for Clinical Data Reporting, Part 1 (Page 19) Spectroscopy - June 2009 - Statistics and Chemometrics for Clinical Data Reporting, Part 1 (Page 20) Spectroscopy - June 2009 - Statistics and Chemometrics for Clinical Data Reporting, Part 1 (Page 21) Spectroscopy - June 2009 - Understanding and Interpreting the New GAMP 5 Software Categories (Page 22) Spectroscopy - June 2009 - Understanding and Interpreting the New GAMP 5 Software Categories (Page 23) Spectroscopy - June 2009 - Understanding and Interpreting the New GAMP 5 Software Categories (Page 24) Spectroscopy - June 2009 - Understanding and Interpreting the New GAMP 5 Software Categories (Page 25) Spectroscopy - June 2009 - Understanding and Interpreting the New GAMP 5 Software Categories (Page 26) Spectroscopy - June 2009 - Understanding and Interpreting the New GAMP 5 Software Categories (Page 27) Spectroscopy - June 2009 - Understanding and Interpreting the New GAMP 5 Software Categories (Page 28) Spectroscopy - June 2009 - Understanding and Interpreting the New GAMP 5 Software Categories (Page 29) Spectroscopy - June 2009 - Understanding and Interpreting the New GAMP 5 Software Categories (Page 30) Spectroscopy - June 2009 - Understanding and Interpreting the New GAMP 5 Software Categories (Page 31) Spectroscopy - June 2009 - Current Status of Standoff LIBS Security Applications at the United States Army Research Laboratory (Page 32) Spectroscopy - June 2009 - Current Status of Standoff LIBS Security Applications at the United States Army Research Laboratory (Page 33) Spectroscopy - June 2009 - Current Status of Standoff LIBS Security Applications at the United States Army Research Laboratory (Page 34) Spectroscopy - June 2009 - Current Status of Standoff LIBS Security Applications at the United States Army Research Laboratory (Page 35) Spectroscopy - June 2009 - Current Status of Standoff LIBS Security Applications at the United States Army Research Laboratory (Page 36) Spectroscopy - June 2009 - Current Status of Standoff LIBS Security Applications at the United States Army Research Laboratory (Page 37) Spectroscopy - June 2009 - Current Status of Standoff LIBS Security Applications at the United States Army Research Laboratory (Page 38) Spectroscopy - June 2009 - Spectral Studies on the Interaction of [Ru(bpy)2(BTIP)]2+ with DNA and Determination of Nucleic Acids at Nanogram Levels (Page 39) Spectroscopy - June 2009 - Spectral Studies on the Interaction of [Ru(bpy)2(BTIP)]2+ with DNA and Determination of Nucleic Acids at Nanogram Levels (Page 40) Spectroscopy - June 2009 - Spectral Studies on the Interaction of [Ru(bpy)2(BTIP)]2+ with DNA and Determination of Nucleic Acids at Nanogram Levels (Page 41) Spectroscopy - June 2009 - Spectral Studies on the Interaction of [Ru(bpy)2(BTIP)]2+ with DNA and Determination of Nucleic Acids at Nanogram Levels (Page 42) Spectroscopy - June 2009 - Spectral Studies on the Interaction of [Ru(bpy)2(BTIP)]2+ with DNA and Determination of Nucleic Acids at Nanogram Levels (Page 43) Spectroscopy - June 2009 - Spectral Studies on the Interaction of [Ru(bpy)2(BTIP)]2+ with DNA and Determination of Nucleic Acids at Nanogram Levels (Page 44) Spectroscopy - 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